Aromasin (Exemestane) – Patient Guide (Australia)
Aromasin (generic name: exemestane) is a medicine used in the treatment of certain hormone-receptor–positive breast cancers. This guide explains what Aromasin is, how it works, how it is typically taken, and important safety and interaction information.
If you have been prescribed Aromasin, follow your clinician’s instructions. This information is written to help you understand your medicine and use it safely.
Basic product information
- Brand name: Aromasin
- Generic name: Exemestane
- Medicinal class: Aromatase inhibitor (AI)
- How it works: Lowers oestrogen production in the body
- Common dosage form: Tablets
- Strengths: Often available as 25 mg tablets (availability may vary by supplier/pharmacy)
- Who it is for: Typically used in postmenopausal women with specific types of hormone-receptor–positive breast cancer
How Aromasin works (mechanism of action)
Aromasin contains exemestane, an aromatase inhibitor. In postmenopausal women, much of the body’s oestrogen is produced when the enzyme aromatase converts hormones called androgens into oestrogens (such as oestrone and oestradiol).
Exemestane works by irreversibly binding to aromatase, reducing oestrogen levels. Because many breast cancers rely on oestrogen to grow, lowering oestrogen can help slow or prevent disease recurrence and reduce tumour activity.
Pharmacokinetics (how the body handles the medicine)
While individual responses vary, the general pharmacokinetic behaviour of exemestane is described below.
- Absorption: Exemestane is absorbed from the gastrointestinal tract. Absorption is improved when taken with food.
- Distribution: It distributes into body tissues, with binding to plasma proteins.
- Metabolism: Exemestane is metabolised mainly in the liver.
- Excretion: Metabolites are excreted primarily via urine and faeces.
- Elimination: Exemestane has a pharmacokinetic profile that supports once-daily dosing in many treatment regimens.
Your clinician may monitor your response through regular follow-up appointments and, when appropriate, blood tests and imaging.
Typical uses and indications
Aromasin is used for breast cancers that are oestrogen-receptor and/or progesterone-receptor positive (commonly referred to as hormone-receptor positive).
Common indications include:
- Early breast cancer: Often used as adjuvant therapy (helping reduce recurrence) in postmenopausal women following initial treatment.
- Advanced or metastatic breast cancer: Treatment of hormone-receptor positive disease in postmenopausal women.
- After other endocrine therapies: May be used after prior treatment with other hormone-related medicines depending on your treatment plan.
Indications can differ based on cancer stage, prior treatments, and individual risk factors. Your clinician can confirm how Aromasin fits into your overall plan.
When to take Aromasin (timing and how to take)
Aromasin is usually taken once daily. Many regimens recommend taking the tablet at the same time each day to help maintain consistent medicine levels.
Recommended timing:
- With food: Taking Aromasin can improve absorption.
- Same time daily: Choose a time that suits your routine (e.g., after breakfast or after dinner).
How to take: Swallow the tablet whole with water. Do not crush or chew unless your pharmacist or clinician advises otherwise. If you miss a dose, follow the “missed dose” guidance in the FAQ below.
Food interactions
Food matters with exemestane. In general, taking Aromasin with food can increase absorption and help ensure you receive the intended dose.
Practical tips:
- Take your dose after eating rather than on an empty stomach.
- If you have a reduced appetite, try taking it right after a small meal or snack.
- Stay consistent day-to-day so your absorption is more predictable.
No specific foods are “forbidden”, but maintaining a regular intake with your dose helps reduce variability.
Alcohol interactions
Alcohol is not typically classified as a direct interaction with exemestane in standard medicine-use guidance. However, alcohol may contribute to side effects such as fatigue, dizziness, hot flushes, mood changes, and nausea.
- If you choose to drink alcohol, do so in moderation.
- Avoid heavy drinking if you feel unwell or if your treatment makes you more sensitive.
- If you develop symptoms after alcohol (e.g., flushing, nausea, sleep disturbance), consider reducing intake and discuss with your clinician.
Some patients also take other medicines for cancer or supportive care. If those medicines interact with alcohol, your clinician or pharmacist can advise you.
Interactions with other medicines
Interactions depend on what other medicines you take, including prescription medicines, over-the-counter products, and supplements. Tell your pharmacist about:
- All prescription medicines
- Over-the-counter medicines (including pain relief, cold/flu medicines, and antacids)
- Herbal products (especially those that affect liver enzymes)
- Vitamin and mineral supplements
Important interaction themes:
- Liver metabolism: Exemestane is metabolised by the liver. Medicines that strongly affect liver enzymes may change exemestane levels.
- Hormone-containing products: Avoid hormone treatments not approved for your regimen (e.g., oestrogen-containing products) unless directed by your clinician.
- CYP-related interactions: Some medicines can influence metabolic pathways. Your pharmacist can check your medication list for relevant interactions.
Examples of items to discuss (not exhaustive):
- Some antibiotics or antifungals
- Some medicines for epilepsy or tuberculosis
- Herbal remedies such as St John’s wort (commonly listed as interacting with various drug pathways)
- Other hormone therapies
Because your complete medication profile matters, always get personalised advice from your pharmacist.
Dosing (typical adult dosing)
The dosing schedule may vary depending on the specific cancer situation and your treatment plan. A common adult regimen for Aromasin in postmenopausal breast cancer is:
| Patient group | Typical dose | Frequency | How to take |
|---|---|---|---|
| Postmenopausal women (as indicated) | 25 mg | Once daily | With food (after a meal) |
Duration: Treatment duration can be months to years depending on the indication, response, and tolerability. Do not stop early without advice from your clinician.
Missed dose (general guidance): If you miss a dose, take it as soon as you remember after food, unless it is close to your next dose. If it is nearly time for the next dose, skip the missed dose—do not double up. See the FAQ for more detail.
Safety profile: common and serious side effects
Like all medicines, Aromasin can cause side effects. Many are manageable, and your care team can help you reduce discomfort. Report new or worsening symptoms promptly.
Common side effects
- Hot flushes (similar to menopausal symptoms)
- Joint or muscle aches (arthralgia, myalgia)
- Fatigue
- Headache
- Nausea
- Sweating
- Sleep disturbance
- Vaginal dryness or changes in vaginal comfort
Bone health (important)
Lowering oestrogen can affect bone density. Aromasin may increase the risk of osteoporosis and fractures over time. Your clinician may recommend:
- Bone density monitoring (e.g., DEXA scans)
- Calcium and vitamin D, if appropriate
- Other bone-protective treatments in selected patients
Serious side effects (seek medical advice urgently)
Get urgent medical help if you experience signs of severe allergy or other serious reactions. Examples include:
- Swelling of the face, lips, tongue or severe skin rash
- Breathing difficulties
- Severe, persistent symptoms such as marked shortness of breath, chest pain, or fainting
When to contact your healthcare team promptly
- New or worsening pain, especially severe joint pain
- Symptoms of depression or significant mood changes
- Any signs of fracture (sudden severe pain after minor injury)
- Abnormal bleeding or unexpected vaginal bleeding (report promptly)
Practical use tips (to help you stay consistent)
- Take it after a meal: This supports absorption and may help reduce stomach upset.
- Use a daily reminder: Phone alarms or a pill organiser can reduce missed doses.
- Manage hot flushes: Dressing in layers, keeping rooms cool, and avoiding triggers (e.g., very hot drinks) may help.
- Support joint comfort: Gentle stretching, regular low-impact activity (e.g., walking), and discussing pain relief options with your pharmacist can help.
- Protect bone health: Discuss bone density tests and consider lifestyle measures such as weight-bearing exercise if suitable.
- Vaginal comfort: Non-hormonal moisturisers or lubricants may help; ask your pharmacist or clinician what is safe for you.
- Track side effects: Keeping a brief symptom diary can help your clinician adjust supportive care if needed.
Special considerations
Who should use Aromasin?
Aromasin is used for postmenopausal women in the settings described by its approved indications. If you are premenopausal or have uncertain menopausal status, your clinician will consider whether exemestane is appropriate, as aromatase inhibitor use generally depends on menopausal status.
Kidney and liver considerations
If you have kidney or liver impairment, dosing decisions may require extra caution. Your pharmacist or clinician can provide guidance based on your medical history.
Pregnancy and breastfeeding
Aromasin is intended for postmenopausal use and is not generally used during pregnancy or breastfeeding. If pregnancy is possible due to your circumstances, discuss contraceptive advice with your clinician.
Alternative options
Depending on your specific cancer type, prior treatments, and tolerance, alternative endocrine therapies may include:
- Other aromatase inhibitors: e.g., anastrozole, letrozole
- Selective oestrogen receptor modulators (SERM): e.g., tamoxifen (depending on indication and menopausal status)
- Selective oestrogen receptor downregulators (SERD) or other endocrine agents: used in particular scenarios under clinician guidance
- Combination or switching strategies: sometimes treatment is changed if side effects are problematic
Your clinician will select an option considering your cancer characteristics, goals of treatment, and your risk of side effects such as bone loss and joint symptoms.
Market and legal context in Australia
In Australia, medicines are regulated by the TGA (Therapeutic Goods Administration) and supplied according to local scheduling rules and clinical guidance. Availability can depend on:
- Whether it is listed and supplied by specific wholesalers
- Pharmacy stock levels and distribution timelines
- Whether the brand or generic formulation is being dispensed
Online pharmacy supply practices in Australia typically require compliance with patient verification processes, identity checks, and medicine ordering rules. Your pharmacy will provide relevant information about how you will receive your medicine and any required documentation.
Always ensure you purchase from an Australian-licensed pharmacy or a legitimate supply channel.
Recent guidance (what matters to patients)
Treatment recommendations for breast cancer endocrine therapy evolve as new evidence and safety information become available. In recent years, common themes in supportive care guidance for aromatase inhibitors have included:
- Bone monitoring and prevention (early assessment and fracture risk management)
- Managing musculoskeletal symptoms (exercise, supportive care, and considering switching if severe)
- Medication adherence support (simple routines, reminders, and side-effect troubleshooting)
- Review of interactions when starting new medicines (including supplements and herbal products)
Your clinician and pharmacist can provide up-to-date, Australia-specific advice tailored to your treatment stage and health history.
Delivery and availability (online pharmacy)
Availability of Aromasin may vary depending on current supply and whether you are purchasing the brand product or generic exemestane. When ordering online, the pharmacy typically provides:
- Estimated dispatch and delivery timeframes
- Cold-chain requirements (if any): not usually required for tablets
- Packaging details: secure, labelled supply
- Tracking information: where available
If a specific brand strength is out of stock, pharmacies may contact you to confirm alternatives. Availability can also depend on your location across Australia.
FAQ
Is Aromasin the same as exemestane?
Yes. Aromasin is the brand name; exemestane is the generic name for the same active ingredient.
How should I take Aromasin?
Take one tablet once daily, usually with food. Swallow it whole with water. Try to take it at the same time each day.
What if I miss a dose?
If you remember soon after the usual time, take the missed dose after food. If it is close to your next dose, skip the missed dose. Do not take two doses together. If you are unsure, ask your pharmacist for advice.
Can I take Aromasin on an empty stomach?
It is generally better to take Aromasin with food because absorption is improved. If you consistently cannot eat, discuss options with your pharmacist or clinician.
What side effects are most common?
Common side effects include hot flushes, fatigue, joint or muscle aches, headache, nausea, and sleep disturbance. Many symptoms can be managed with supportive care.
Does Aromasin affect my bones?
It can. By lowering oestrogen levels, Aromasin may reduce bone mineral density and increase fracture risk. Your clinician may recommend bone density monitoring and bone-protective measures.
Is it safe to drink alcohol while taking Aromasin?
Alcohol is not usually described as a direct interaction, but it can worsen side effects for some people. Keep alcohol to moderation and discuss with your clinician if you notice symptoms.
What medicines and supplements should I avoid?
Do not start new medicines or herbal supplements without checking with your pharmacist, especially products that may affect liver enzymes or contain hormones. Keep your pharmacist updated with your full list of medicines and supplements.
When should I seek urgent medical help?
Seek urgent help if you develop signs of a severe allergic reaction (such as facial swelling, breathing difficulty, or severe rash), or other severe symptoms.
What can I do if my joints hurt?
Many patients experience joint stiffness or pain. Supportive measures may include gentle exercise, stretching, and discussing pain relief options with your pharmacist. If symptoms are severe, your clinician may review your treatment plan.
Are there alternatives if Aromasin doesn’t suit me?
Yes. Options may include other aromatase inhibitors (anastrozole, letrozole) or other endocrine treatments depending on your indication and treatment history.
Summary
Aromasin (exemestane) is an aromatase inhibitor used in hormone-receptor–positive breast cancer in postmenopausal women. By reducing oestrogen production, it helps limit the hormonal signals that can drive cancer growth. For best absorption, take it once daily with food. Pay attention to bone health, watch for common side effects like hot flushes and joint aches, and keep your healthcare team informed about other medicines and supplements.

